Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection

Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection

Monday, January 1, 2018

This analysis of early mucosal infections in women revealed high HIV-1 viral diversity in the vaginal tract but few transmitted clones in the blood. This provides novel in vivo evidence for a mucosal sieve effect, leading to the establishment of a homogenous systemic infection. The data will have significant implications in rational vaccine design.

PLoS Pathog 2018 Jan; 14(1): e1006754. [Journal Impact Factor: 6.608] Klein K, Nickel G, Nankya I, Kyeyune F, Demers K, Ndashimye E, Kwok C, Chen PL, Rwambuya S, Poon A, Munjoma M, Chipato T, Byamugisha J, Mugyenyi P, Salata RA, Morrison CS, Arts EJ Health and access to careHealth researchHealth surveillanceHealth systems strengtheningHIV and AIDSGenderHealthResearchData analysisGlobal research servicesMonitoring and evaluationQuality assurance